姓名： 张春云
职称、职务： 教授、博士生导师 生态学系系主任
电子邮箱： cyzhang@hubu.edu.cn
通信地址：武汉市武昌区友谊大道368号湖北大学资源环境学院
联系电话：027-88661699-8056
主要研究方向
毒性污染物的代谢转化：采用高分辨质谱及信息化数据处理技术解析有机污染物的代谢转化及其与内源性分子结合等产生毒性的关键分子起始事件
教育背景
2007.09-2010.06 齐鲁工业大学, 轻化与环境工程学院, 学士
2010.09-2015.06 华南理工大学, 轻工与食品学院, 博士
工作经历
2015.08-2021.12 中国科学院武汉植物园 助理/副研究员
2018.04-2021.04 美国爱荷华大学 职业与环境卫生系 博士后
2022.01- 湖北大学 资源环境学院 教授
教学课程
生物化学、污染物监测及评价、污染物监测及评价实验、博士研究生论文写作指导
主要社会兼职
中国药文化研究会健康促进分会专家委员、黄石市企业科技特派员、期刊Environ. Sci. & Technol., J. Hazard. Mater.等审稿人
荣誉和获奖情况
2024年，湖北省省级人才资助；
2014年，获得华南理工大学优秀博士论文创新基金二等资助；
2008年，获得国家励志奖学金；
承担（主持）的主要科研项目
1. 国家自然科学基金面上项目，多氯联苯经高活性邻二酚型代谢节点致毒与解毒代谢触发的优先机制研究，22376056，2024/01-2027/12，主持；
2. 湖北省自然科学基金杰出青年基金（青年A类），人体主要器官新污染物暴露图谱构建及安全评价，2025AFA100，2025/03-2028/03，在研，主持；
3. 国家自然科学基金重大科研仪器研制项目，基于原位取样质谱的多尺度血脑屏障递送机制分析系统，22327805，2024/01-2028/12，项目骨干；
4. 武汉市知识创新专项基础研究项目，喹诺酮类抗生素突破细菌耐药性的内源性代谢物辅剂筛选，202210801251323，2022/06-2024/06，主持；
5. 区域开发与环境响应湖北省重点实验室，光电子废物拆解地有机污染物的质谱非靶标筛查，2022(C)002，2023/02-2025/02，主持；
6. 美国国立卫生研究院（NIH）通过爱荷华大学环境与健康科学研究中心（EHSRC）资助的试点项目，真实空气污染对阿尔兹海默症临床前大鼠模型血清炎症消退因子的影响，ES005605, 2020/04-2021/04，主持；
7. 国家自然科学基金青年基金，3160180020，2017/01-2019/12，主持；
8. 湖北省自然科学基金，2016CFB285, 2016/01-2017/12，主持；
代表性论文
1. Chun-Yun Zhang, Xueshu Li, Kimberly P. Keil Stietz, Sunjay Sethi, Weizhu Yang, Rachel F. Marek, Xinxin Ding, Pamela J. Lein, Keri C. Hornbuckle, Hans-Joachim Lehmler*. Machine Learning-Assisted Identification and Quantification of Hydroxylated Metabolites of Polychlorinated Biphenyls in Animal Samples. Environmental Science & Technology 2022, 56, 13169-13178.
2. Chun-Yun Zhang, Xueshu Li, Susanne Flor, Patricia Ruiz, Anneli Kruve, Gabriele Ludewig, Hans-Joachim Lehmler*. Metabolism of 3‑Chlorobiphenyl (PCB 2) in a Human-Relevant Cell Line: Evidence of Dechlorinated Metabolites. Environmental Science & Technology 2022, 56, 12460-12472.
3. Chun-Yun Zhang, Susanne Flor, Patricia Ruiz, Gabriele Ludewig, Hans-Joachim Lehmler*. Characterization of the Metabolic Pathways of 4-Chlorobiphenyl (PCB3) in HepG2 Cells Using the Metabolite Profiles of Its Hydroxylated Metabolites. Environmental Science & Technology 2021, 55, 9052-9062.
4. Chun-Yun Zhang, Susanne Flor, Gabriele Ludewig, Hans-Joachim Lehmler*. Atropselective partitioning of polychlorinated biphenyls in a HepG2 cell culture system: experimental and modeling results. Environmental Science & Technology 2020, 54, 13817-13827.
5. Chun-Yun Zhang, Susanne Flor, Patricia Ruiz, Ram Dhakal, Xin Hu, Lynn M. Teesch, Gabriele Ludewig, Hans-Joachim Lehmler*. 3,3’-Dichlorobiphenyl is metabolized to a complex mixture of oxidative metabolites, including novel methoxylated metabolites, by HepG2 cells. Environmental Science & Technology 2020, 54, 12345-12357.
其它论文
1. Hui-Jun Jin, Zi-Dong Qiu, Chun-Yun Zhang*, Yu Peng. Integrated mammalian cell culture and growth measurement using headspace analysis: experimental and modeling results, Journal of Chromatography A 2025, 1751,465947.
2. Hui-Jun Jin, Zi-Dong Qiu, Cen Qian, Chun-Yun Zhang*; Yu Peng*. Identification of the metabolomic alterations associated with the formation of bisphenol-A sulfate metabolite in HepG2 cells, Food and Chemical Toxicology 2025, 200,115382.
3. Chun-Yun Zhang, Xueshu Li, Kimberly P. Keil Stietz, Sunjay Sethi, Weizhu Yang, Rachel F. Marek, Xinxin Ding, Pamela J. Lein, Keri C. Hornbuckle, Hans-Joachim Lehmler*. Rebuttal to Correspondence on “Machine Learning-Assisted Identification and Quantification of Hydroxylated Metabolites of Polychlorinated Biphenyls in Animal Samples” Environmental Science & Technology 2023, 57, 6251-6252.
4. Chun-Yun Zhang, Teng-Fei Li, Xin-Sheng Chai*, Xian-Ming Xiao. Determination of porosity in shale by double headspace extraction GC analysis. Analytical Chemistry 2015, 87, 11072-111077.
5. Chun-Yun Zhang, Qiong Zhang, Cai-Hong Zhong, Ming-Quan Guo*. Volatile fingerprints and biomarkers of three representative kiwifruit cultivars obtained by headspace solid-phase microextraction gas chromatography mass spectrometry and chemometrics. Food Chemistry 2019, 271, 211-215.
6. Chun-Yun Zhang, Neng-Biao Lin, Xin-Sheng Chai*, Zhong Li. A rapid method for simultaneously determining ethanol and methanol content in wines by full evaporation headspace gas chromatography. Food Chemistry 2015, 183, 169-172.
7. Chun-Yun Zhang, Carolyn R. Klocke, Pamela J. Lein, Hans-Joachim Lehmler*. Disposition of PCB 11 in Mice Following Acute Oral Exposure. Chemical Research in Toxicology 2021, 34, 988-991.
8. Chun-Yun Zhang, Xin-Sheng Chai*, Xian-Ming Xiao. A simple method for correcting for the presence of minor gases when determining the adsorbed methane content in shale. Fuel 2015, 150:334-338.
9. Chun-Yun Zhang#, Meng-Hui Li#, Ming-Quan Guo*. A phase conversion headspace technique for the determination of anti-anaerobic activity of drug candidate based on the metabolic acidity change in culture medium. Journal of Chromatography A 2020, 1621, 461024.
10. Chun-Yun Zhang#, Meng-Hui Li#, Gui-Lin Chen, Ming-Quan Guo*. In-situ headspace analysis of metabolic carbon dioxide of aerobic bacteria for assessing antimicrobial activity of natural products. Journal of Chromatography A 2019, 1600, 41-45.
11. Chun-Yun Zhang, Ming-Quan Guo*. Solvent-saturated solid matrix technique for increasing the efficiency of headspace extraction of volatiles. Journal of Chromatography A 2017, 1511, 9-14.
12. Chun-Yun Zhang, Qiong Zhang, Cai-Hong Zhong, Ming-Quan Guo*. Analysis of volatile compounds responsible for kiwifruit aroma by desiccated headspace gas chromatography-mass spectrometry. Journal of Chromatography A 2016, 1440:255-259.
13. Chun-Yun Zhang, Xin-Sheng Chai*. A novel multiple headspace extraction gas chromatography method for measuring the diffusion coefficient of methanol in water and olive oil. Journal of Chromatography A 2015, 1385:124-128.
14. Chun-Yun Zhang, Hui-Chao Hu, Xin-Sheng Chai*, Pan Lei, Xian-Ming Xiao. Determination of maximal amount of minor gases adsorbed in a shale sample by headspace gas chromatography. Journal of Chromatography A 2014, 1328:80-84.
15. Chun-Yun Zhang, Ling-Ling Li, Xin-Sheng Chai*, Donald G. Barnes. Rapid determination of methanol content in paper materials by alkaline extraction coupled with headspace analysis. Journal of Chromatography A 2014, 1350:10-14.
16. Chun-Yun Zhang, Hui-Chao Hu, Xin-Sheng Chai*, Pan Lei, Xian-Ming Xiao. A novel method for the determination of adsorption partition coefficient of minor gases in a shale sample by headspace gas chromatography. Journal of Chromatography A 2013, 1310:121-125.
17. Chun-Yun Zhang, Ming-Quan Guo*. Analysis and differentiation of the volatile compounds in red and white wines using desiccated headspace gas chromatography-mass spectrometry coupled with chemometrics. Food Analytical Methods 2017, 10, 3531-3537.
专利
1. 张春云等. 天然产物对厌氧菌抗菌活性的测定方法及应用, 2020, 中国发明专利, ZL202010149072.8.
2. 张春云等. 一种用于生物培养的厌氧瓶定量等压除氧装置及方法, 2020, 中国发明专利, ZL202010822915.6.
3. 郭明全, 陈桂林, 田永强, 张春云. 一种快速筛选天然产物中拓扑异构酶I抑制剂的方法, 2017, 中国发明专利, ZL201610249760.5.
学术报告
1. Chun-Yun Zhang. Airborne polychlorinated biphenyls: metabolism and associated metabolomic alterations. EHSRC/Superfund/Toxicology seminar, Invited Oral Presentation, University of Iowa, Iowa City, Iowa, USA, Apr 02, 2021.
2. Chun-Yun Zhang, Susanne Flor, Gabriele Ludewig, Hans-Joachim Lehmler. Elucidation of the metabolic pathways of 4-chlorobiphenyl (PCB3) in HepG2 cells using a set of hydroxylated metabolites. Central States Chapter of the Society of Toxicology 2020 Annual Meeting, Short Oral presentation, Virtual Platform, Oct 16, 2020.
3. Chun-Yun Zhang, Susanne Flor, Gabriele Ludewig, Hans-Joachim Lehmler. Metabolite profiles of a set of hydroxylated metabolites facilitate the identification of the metabolic pathways of 4-chlorobiphenyls (PCB 3) in HepG2 cells. 2020 Annual Meeting of Superfund Research Program, Poster presentation. Virtual Platform, Dec 15, 2020.
4. Chun-Yun Zhang, Susanne Flor, Gabriele Ludewig, Hans-Joachim Lehmler. Enantioselective partitioning of polychlorinated biphenyls (PCBs) in a HepG2 cell culture system. Central States Chapter of the Society of Toxicology 2019 Annual Meeting, Poster presentation, Drake University, Des Moines, Iowa, USA, Sep 27, 2019.
5. Chun-Yun Zhang, Susanne Flor, Ram Dhakal, Xueshu Li, Lynn M. Teesch, Gabriele Ludewig, Hans-Joachim Lehmler. Metabolism of non-Aroclor 3,3’-dichlorobiphenyl (PCB 11) in human hepatoma (HepG2) cells. Central States Chapter of the Society of Toxicology 2018 Annual Meeting, Poster presentation, Kansas State University, Manhattan, Kansas, USA, Oct 18-19, 2018.
其它
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